Signaling by 4-hydroxy-2-nonenal: Exposure protocols, target selectivity and degradation
نویسندگان
چکیده
منابع مشابه
IkappaB kinase, a molecular target for inhibition by 4-hydroxy-2-nonenal.
In unstimulated cells, transcription factor NF-kappaB is retained in the cytoplasm by interaction with the inhibitory protein, IkappaBalpha. Appropriate cellular stimuli inactivate IkappaBalpha by phosphorylation, ubiquination, and proteolytic degradation, which allows NF-kappaB to translocate to the nucleus and modulate gene expression. 4-Hydroxy-2-nonenal (HNE), a major lipid peroxidation pro...
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ژورنال
عنوان ژورنال: Archives of Biochemistry and Biophysics
سال: 2017
ISSN: 0003-9861
DOI: 10.1016/j.abb.2016.11.003